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  1. Research

    Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44

    A targeted drug nanoparticle (NP) delivery system has shown potential as a possible cancer treatment. Given its merits, such as its selective distribution at tumor sites and its controllable drug release, drug...

    Tao Wang, Jiahui Hou, Chang Su, Liang Zhao and Yijie Shi

    Journal of Nanobiotechnology 2017 15:7

    Published on: 10 January 2017

  2. Review

    Interaction of biomedical nanoparticles with the pulmonary immune system

    Engineered nanoparticles (NPs) offer site-specific delivery, deposition and cellular uptake due to their unique physicochemical properties and were shown to modulate immune responses. The respiratory tract wit...

    Fabian Blank, Kleanthis Fytianos, Emilie Seydoux, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Christophe von Garnier and Barbara Rothen-Rutishauser

    Journal of Nanobiotechnology 2017 15:6

    Published on: 9 January 2017

  3. Research

    Cytotoxic effects of nanosilver are highly dependent on the chloride concentration and the presence of organic compounds in the cell culture media

    Nanosilver shows great promise for use in industrial, consumer or medical products because of its antimicrobial properties. However, the underlying mechanisms of the effects of silver nanoparticles on human ce...

    Jean-Pierre Kaiser, Matthias Roesslein, Liliane Diener, Adrian Wichser, Bernd Nowack and Peter Wick

    Journal of Nanobiotechnology 2017 15:5

    Published on: 6 January 2017

  4. Research

    Antioxidant capacities of the selenium nanoparticles stabilized by chitosan

    Selenium (Se) as one of the essential trace elements for human plays an important role in the oxidation reduction system. But the high toxicity of Se limits its application. In this case, the element Se with z...

    Xiaona Zhai, Chunyue Zhang, Guanghua Zhao, Serge Stoll, Fazheng Ren and Xiaojing Leng

    Journal of Nanobiotechnology 2017 15:4

    Published on: 5 January 2017

  5. Research

    Elasto-inertial microfluidics for bacteria separation from whole blood for sepsis diagnostics

    Bloodstream infections (BSI) remain a major challenge with high mortality rate, with an incidence that is increasing worldwide. Early treatment with appropriate therapy can reduce BSI-related morbidity and mor...

    Muhammad Asim Faridi, Harisha Ramachandraiah, Indradumna Banerjee, Sahar Ardabili, Sergey Zelenin and Aman Russom

    Journal of Nanobiotechnology 2017 15:3

    Published on: 4 January 2017

  6. Research

    Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

    Preparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, si...

    Anna E. M. F. M. Oliveira, Jonatas L. Duarte, Rodrigo A. S. Cruz, Raimundo N. P. Souto, Ricardo M. A. Ferreira, Taires Peniche, Edemilson C. da Conceição, Leandra A. R. de Oliveira, Silvia M. M. Faustino, Alexandro C. Florentino, José C. T. Carvalho and Caio P. Fernandes

    Journal of Nanobiotechnology 2017 15:2

    Published on: 3 January 2017

  7. Research

    Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines

    Nanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale. One application of this technology is drug delivery systems based on nanoparticles...

    Juan P. Peñaloza, Valeria Márquez-Miranda, Mauricio Cabaña-Brunod, Rodrigo Reyes-Ramírez, Felipe M. Llancalahuen, Cristian Vilos, Fernanda Maldonado-Biermann, Luis A. Velásquez, Juan A. Fuentes, Fernando D. González-Nilo, Maité Rodríguez-Díaz and Carolina Otero

    Journal of Nanobiotechnology 2017 15:1

    Published on: 3 January 2017

  8. Research

    Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer

    Functionalized nanoparticles (NPs) are one promising tool for detecting specific molecular targets and combine molecular biology and nanotechnology aiming at modern imaging. We aimed at ligand-directed deliver...

    Sophie Dobiasch, Szilard Szanyi, Aleko Kjaev, Jens Werner, Albert Strauss, Christian Weis, Lars Grenacher, Katya Kapilov-Buchman, Liron-Limor Israel, Jean-Paul Lellouche, Erica Locatelli, Mauro Comes Franchini, Jennifer Vandooren, Ghislain Opdenakker and Klaus Felix

    Journal of Nanobiotechnology 2016 14:81

    Published on: 19 December 2016

  9. Research

    Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging

    Multifunctional nanocarriers for controlled drug delivery, imaging of disease development and follow-up of treatment efficacy are promising novel tools for disease diagnosis and treatment. In the current inves...

    Heba Asem, Ying Zhao, Fei Ye, Åsa Barrefelt, Manuchehr Abedi-Valugerdi, Ramy El-Sayed, Ibrahim El-Serafi, Khalid M. Abu-Salah, Jörg Hamm, Mamoun Muhammed and Moustapha Hassan

    Journal of Nanobiotechnology 2016 14:82

    Published on: 19 December 2016

  10. Research

    Targeted drug delivery of near IR fluorescent doxorubicin-conjugated poly(ethylene glycol) bisphosphonate nanoparticles for diagnosis and therapy of primary and metastatic bone cancer in a mouse model

    Most primary and metastatic bone tumors demonstrate increased osteoclast activity and bone resorption. Current treatment is based on a combination of surgery, radiotherapy and chemotherapy. Severe side effects...

    S. Rudnick-Glick, E. Corem-Salkmon, I. Grinberg and S. Margel

    Journal of Nanobiotechnology 2016 14:80

    Published on: 5 December 2016

  11. Review

    A critical review of the current knowledge regarding the biological impact of nanocellulose

    Several forms of nanocellulose, notably cellulose nanocrystals and nanofibrillated cellulose, exhibit attractive property matrices and are potentially useful for a large number of industrial applications. Thes...

    C. Endes, S. Camarero-Espinosa, S. Mueller, E. J. Foster, A. Petri-Fink, B. Rothen-Rutishauser, C. Weder and M. J. D. Clift

    Journal of Nanobiotechnology 2016 14:78

    Published on: 1 December 2016

  12. Research

    Release of copper-amended particles from micronized copper-pressure-treated wood during mechanical abrasion

    We investigated the particles released due to abrasion of wood surfaces pressure-treated with micronized copper azole (MCA) wood preservative and we gathered preliminary data on its in vitro cytotoxicity for l...

    Chiara Civardi, Lukas Schlagenhauf, Jean-Pierre Kaiser, Cordula Hirsch, Claudio Mucchino, Adrian Wichser, Peter Wick and Francis W. M. R. Schwarze

    Journal of Nanobiotechnology 2016 14:77

    Published on: 28 November 2016

  13. Research

    Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen

    Zinc oxide nanoparticle (ZNP) has been applied in various biomedical fields. Here, we investigated the usage of ZNP as an antigen carrier for vaccine development by combining a high affinity peptide to ZNP.

    Na-Young Ha, Hyun Mu Shin, Prashant Sharma, Hyun Ah Cho, Chan-Ki Min, Hong-il Kim, Nguyen Thi Hai Yen, Jae-Seung Kang, Ik-Sang Kim, Myung-Sik Choi, Young Keun Kim and Nam-Hyuk Cho

    Journal of Nanobiotechnology 2016 14:76

    Published on: 26 November 2016

  14. Methodology

    High efficiency penetration of antibody-immobilized nanoneedle thorough plasma membrane for in situ detection of cytoskeletal proteins in living cells

    The field of structural dynamics of cytoskeletons in living cells is gathering wide interest, since better understanding of cytoskeleton intracellular organization will provide us with not only insights into b...

    R. Kawamura, K. Shimizu, Y. Matsumoto, A. Yamagishi, Y. R. Silberberg, M. Iijima, S. Kuroda, K. Fukazawa, K. Ishihara and C. Nakamura

    Journal of Nanobiotechnology 2016 14:74

    Published on: 3 November 2016

  15. Research

    Lipid nanoemulsions and liposomes improve photodynamic treatment efficacy and tolerance in CAL-33 tumor bearing nude mice

    Photodynamic therapy (PDT) as promising alternative to conventional cancer treatments works by irradiation of a photosensitizer (PS) with light, which creates reactive oxygen species and singlet oxygen (1O2), tha...

    Doris Hinger, Susanna Gräfe, Fabrice Navarro, Bernhard Spingler, Devaraj Pandiarajan, Heinrich Walt, Anne-Claude Couffin and Caroline Maake

    Journal of Nanobiotechnology 2016 14:71

    Published on: 3 October 2016

  16. Research

    The impact of species and cell type on the nanosafety profile of iron oxide nanoparticles in neural cells

    While nanotechnology is advancing rapidly, nanosafety tends to lag behind since general mechanistic insights into cell-nanoparticle (NP) interactions remain rare. To tackle this issue, standardization of nanos...

    Freya Joris, Daniel Valdepérez, Beatriz Pelaz, Stefaan J. Soenen, Bella B. Manshian, Wolfgang J. Parak, Stefaan C. De Smedt and Koen Raemdonck

    Journal of Nanobiotechnology 2016 14:69

    Published on: 9 September 2016

  17. Research

    Photoinduced effects of m-tetrahydroxyphenylchlorin loaded lipid nanoemulsions on multicellular tumor spheroids

    Photosensitizers are used in photodynamic therapy (PDT) to destruct tumor cells, however, their limited solubility and specificity hampers routine use, which may be overcome by encapsulation. Several promising...

    Doris Hinger, Fabrice Navarro, Andres Käch, Jean-Sébastien Thomann, Frédérique Mittler, Anne-Claude Couffin and Caroline Maake

    Journal of Nanobiotechnology 2016 14:68

    Published on: 7 September 2016

  18. Research

    Magnetocontrollability of Fe7C3@C superparamagnetic nanoparticles in living cells

    A new type of superparamagnetic nanoparticles with chemical formula Fe7C3@C (MNPs) showed higher value of magnetization compared to traditionally used iron oxide-based nanoparticles as was shown in our previou...

    Irina B. Alieva, Igor Kireev, Anastasia S. Garanina, Natalia Alyabyeva, Antoine Ruyter, Olga S. Strelkova, Oxana A. Zhironkina, Varvara D. Cherepaninets, Alexander G. Majouga, Valery A. Davydov, Valery N. Khabashesku, Viatcheslav Agafonov and Rustem E. Uzbekov

    Journal of Nanobiotechnology 2016 14:67

    Published on: 30 August 2016

  19. Review

    Zebrafish: A complete animal model to enumerate the nanoparticle toxicity

    Presently, nanotechnology is a multi-trillion dollar business sector that covers a wide range of industries, such as medicine, electronics and chemistry. In the current era, the commercial transition of nanote...

    Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma and Sang-Soo Lee

    Journal of Nanobiotechnology 2016 14:65

    Published on: 20 August 2016

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