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  1. Research

    Synthesis, characterization, and biological verification of anti-HER2 indocyanine green–doxorubicin-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions for targeted photochemotherapy of breast cancer cells

    Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-ov...

    Yu-Hsiang Lee and Yun-Ting Ma

    Journal of Nanobiotechnology 2017 15:41

    Published on: 18 May 2017

  2. Research

    Label-free biosensing of Salmonella enterica serovars at single-cell level

    The emerging nanotechnologies have greatly facilitated the development of label-free biosensors. The atomic force microscopy (AFM) has been used to study the molecular mechanism of the reactions for protein an...

    Bin Wang, Bosoon Park, Bingqian Xu and Yongkuk Kwon

    Journal of Nanobiotechnology 2017 15:40

    Published on: 17 May 2017

  3. Short Communication

    Tracking single baculovirus retrograde transportation in host cell via quantum dot-labeling of virus internal component

    Quantum dot (QD)-based single virus tracking has become a powerful tool for dissecting virus infection mechanism. However, only virus behaviors at the early stage of retrograde trafficking have been dynamicall...

    Li Wen, Zhen-Hua Zheng, An-An Liu, Cheng Lv, Li-Juan Zhang, Jian Ao, Zhi-Ling Zhang, Han-Zhong Wang, Yi Lin and Dai-Wen Pang

    Journal of Nanobiotechnology 2017 15:37

    Published on: 6 May 2017

  4. Research

    A mechanistic investigation exploring the differential transfection efficiencies between the easy-to-transfect SK-BR3 and difficult-to-transfect CT26 cell lines

    Gold–polyamidoamine (AuPAMAM) has previously been shown to successfully transfect cells with high efficiency. However, we have observed that certain cell types are more amenable to Au–PAMAM transfection than o...

    Elizabeth Figueroa, Pallavi Bugga, Vishwaratn Asthana, Allen L. Chen, J. Stephen Yan, Emily Reiser Evans and Rebekah A. Drezek

    Journal of Nanobiotechnology 2017 15:36

    Published on: 2 May 2017

  5. Research

    Highly sensitive and accurate detection of C-reactive protein by CdSe/ZnS quantum dot-based fluorescence-linked immunosorbent assay

    The conventional and widely used enzyme-linked immunosorbent assays (ELISA), due to specificity and high-sensitivity, were suitable in vitro diagnosis. But enzymes are vulnerable to the external conditions, an...

    Yanbing Lv, Ruili Wu, Kunrui Feng, Jinjie Li, Qing Mao, Hang Yuan, Huaibin Shen, Xiangdong Chai and Lin Song Li

    Journal of Nanobiotechnology 2017 15:35

    Published on: 2 May 2017

  6. Research

    A retro-inverso cell-penetrating peptide for siRNA delivery

    Small interfering RNAs (siRNAs) are powerful tools to control gene expression. However, due to their poor cellular permeability and stability, their therapeutic development requires a specific delivery system....

    Anaïs Vaissière, Gudrun Aldrian, Karidia Konate, Mattias F. Lindberg, Carole Jourdan, Anthony Telmar, Quentin Seisel, Frédéric Fernandez, Véronique Viguier, Coralie Genevois, Franck Couillaud, Prisca Boisguerin and Sébastien Deshayes

    Journal of Nanobiotechnology 2017 15:34

    Published on: 28 April 2017

  7. Review

    Nanoparticles based on essential metals and their phytotoxicity

    Nanomaterials in agriculture are becoming popular due to the impressive advantages of these particles. However, their bioavailability and toxicity are key features for their massive employment. Herein, we comp...

    Branislav Ruttkay-Nedecky, Olga Krystofova, Lukas Nejdl and Vojtech Adam

    Journal of Nanobiotechnology 2017 15:33

    Published on: 26 April 2017

  8. Research

    Aggregation/dispersion transitions of T4 phage triggered by environmental ion availability

    Bacteriophage survives in at least two extremes of ionic environments: bacterial host (high ionic-cytosol) and that of soil (low ionic-environmental water). The impact of ionic composition in the micro- and macro...

    Bożena Szermer-Olearnik, Marek Drab, Mateusz Mąkosa, Maria Zembala, Jakub Barbasz, Krystyna Dąbrowska and Janusz Boratyński

    Journal of Nanobiotechnology 2017 15:32

    Published on: 24 April 2017

  9. Research

    Chitosan nanoparticle-mediated co-delivery of shAtg-5 and gefitinib synergistically promoted the efficacy of chemotherapeutics through the modulation of autophagy

    Autophagy reportedly plays vital and complex roles in many diseases. During times of starvation or energy deficiency, autophagy will occur at higher levels to provide cells with the nutrients or energy necessa...

    Yan Zheng, Chang Su, Liang Zhao and Yijie Shi

    Journal of Nanobiotechnology 2017 15:28

    Published on: 11 April 2017

  10. Review

    Vectorized nanodelivery systems for ischemic stroke: a concept and a need

    Neurological diseases of diverse aetiologies have significant effects on the quality of life of patients. The limited self-repairing capacity of the brain is considered to be the origin of the irreversible and...

    Andrés Da Silva-Candal, Bárbara Argibay, Ramón Iglesias-Rey, Zulema Vargas, Alba Vieites-Prado, Esteban López-Arias, Emilio Rodríguez-Castro, Iria López-Dequidt, Manuel Rodríguez-Yáñez, Yolanda Piñeiro, Tomás Sobrino, Francisco Campos, José Rivas and José Castillo

    Journal of Nanobiotechnology 2017 15:30

    Published on: 11 April 2017

  11. Research

    Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging

    Tracking targets of natural products is one of the most challenging issues in fields ranging from pharmacognosy to biomedicine. It is widely recognized that the biocompatible nanoparticle (NP) could function a...

    Qingxin Cui, Yuanyuan Hou, Yanan Wang, Xu Li, Yang Liu, Xiaoyao Ma, Zengyong Wang, Weiya Wang, Jin Tao, Qian Wang, Min Jiang, Dongyan Chen, Xizeng Feng and Gang Bai

    Journal of Nanobiotechnology 2017 15:27

    Published on: 7 April 2017

  12. Research

    Multi-walled carbon nanotubes functionalized with recombinant Dengue virus 3 envelope proteins induce significant and specific immune responses in mice

    Dengue is the most prevalent arthropod-borne viral disease in the world. In this article we present results on the development, characterization and immunogenic evaluation of an alternative vaccine candidate a...

    Alice F. Versiani, Ruiz G. Astigarraga, Eliseu S. O. Rocha, Ana Paula M. Barboza, Erna G. Kroon, Milene A. Rachid, Daniele G. Souza, Luiz O. Ladeira, Edel F. Barbosa-Stancioli, Ado Jorio and Flávio G. Da Fonseca

    Journal of Nanobiotechnology 2017 15:26

    Published on: 4 April 2017

  13. Review

    Development of nanoparticle-based optical sensors for pathogenic bacterial detection

    Pathogenic bacteria contribute to various globally important diseases, killing millions of people each year. Various fields of medicine currently benefit from or may potentially benefit from the use of nanotec...

    Teodora Mocan, Cristian T. Matea, Teodora Pop, Ofelia Mosteanu, Anca Dana Buzoianu, Cosmin Puia, Cornel Iancu and Lucian Mocan

    Journal of Nanobiotechnology 2017 15:25

    Published on: 31 March 2017

  14. Research

    Optimizing conditions for labeling of mesenchymal stromal cells (MSCs) with gold nanoparticles: a prerequisite for in vivo tracking of MSCs

    Mesenchymal stromal cells (MSCs) have an inherent migratory capacity towards tumor tissue in vivo. With the future objective to quantify the tumor homing efficacy of MSCs, as first step in this direction we in...

    Philipp Nold, Raimo Hartmann, Neus Feliu, Karsten Kantner, Mahmoud Gamal, Beatriz Pelaz, Jonas Hühn, Xing Sun, Philipp Jungebluth, Pablo del Pino, Holger Hackstein, Paolo Macchiarini, Wolfgang J. Parak and Cornelia Brendel

    Journal of Nanobiotechnology 2017 15:24

    Published on: 29 March 2017

  15. Methodology

    Real-time, label-free monitoring of cell viability based on cell adhesion measurements with an atomic force microscope

    The adhesion of cells to an oscillating cantilever sensitively influences the oscillation amplitude at a given frequency. Even early stages of cytotoxicity cause a change in the viscosity of the cell membrane ...

    Fang Yang, René Riedel, Pablo del Pino, Beatriz Pelaz, Alaa Hassan Said, Mahmoud Soliman, Shashank R. Pinnapireddy, Neus Feliu, Wolfgang J. Parak, Udo Bakowsky and Norbert Hampp

    Journal of Nanobiotechnology 2017 15:23

    Published on: 22 March 2017

  16. Research

    Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry

    We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versa...

    André G. Próspero, Caio C. Quini, Andris F. Bakuzis, Patrícia Fidelis-de-Oliveira, Gustavo M. Moretto, Fábio P. F. Mello, Marcos F. F. Calabresi, Ronaldo V. R. Matos, Ednaldo A. Zandoná, Nícholas Zufelato, Ricardo B. Oliveira and José R. A. Miranda

    Journal of Nanobiotechnology 2017 15:22

    Published on: 21 March 2017

  17. Research

    Quantification of silver nanoparticle uptake and distribution within individual human macrophages by FIB/SEM slice and view

    Quantification of nanoparticle (NP) uptake in cells or tissues is very important for safety assessment. Often, electron microscopy based approaches are used for this purpose, which allow imaging at very high r...

    Erik Guehrs, Michael Schneider, Christian M. Günther, Piet Hessing, Karen Heitz, Doreen Wittke, Ana López-Serrano Oliver, Norbert Jakubowski, Johanna Plendl, Stefan Eisebitt and Andrea Haase

    Journal of Nanobiotechnology 2017 15:21

    Published on: 21 March 2017

  18. Research

    Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation

    Selenium (Se) is an essential micronutrient trace element and an established nutritional antioxidant. Low Se status exacerbates inflammatory bowel diseases progression, which involves hyper inflammation in the...

    Chenghui Zhu, Shuimei Zhang, Chengwei Song, Yibo Zhang, Qinjie Ling, Peter R. Hoffmann, Jun Li, Tianfeng Chen, Wenjie Zheng and Zhi Huang

    Journal of Nanobiotechnology 2017 15:20

    Published on: 7 March 2017

  19. Review

    Non-invasive continuous monitoring of pro-oxidant effects of engineered nanoparticles on aquatic microorganisms

    Engineered nanomaterials (ENMs) are key drivers for the development of highly sophisticated new technologies. As all new attainments, the rapidly increasing used of ENMs raise concerns about their safety for t...

    Christian Santschi, Nadia Von Moos, Volodymyr B. Koman, Vera I. Slaveykova, Paul Bowen and Olivier J. F. Martin

    Journal of Nanobiotechnology 2017 15:19

    Published on: 7 March 2017

  20. Research

    Understanding cellular internalization pathways of silicon nanowires

    Understanding how cells interact with nanomaterials is important for rational design of nanomaterials for nanomedicine and transforming them for clinical applications. Particularly, the mechanism for one-dimen...

    Kelly McNear, Yimin Huang and Chen Yang

    Journal of Nanobiotechnology 2017 15:17

    Published on: 1 March 2017

  21. Research

    Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy

    Diabetic retinopathy is the most common complication in diabetic patients relates to high expression of VEGF and microaneurysms. Scutellarin (Scu) turned out to be effective against diabetes related vascular e...

    Jingnan Wang, Jiayun Tan, Jiahao Luo, Peilin Huang, Wuyi Zhou, Luming Chen, Lingli Long, Li-ming Zhang, Banghao Zhu, Liqun Yang and David Y. B. Deng

    Journal of Nanobiotechnology 2017 15:18

    Published on: 1 March 2017

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