Figure 6

Structure of the streptavidin protein. Panel A – A 3D structure of the streptavidin protein (PDP Acc.No. 1STP) showing a biotin binding site (left) and the side-most amino acid chain loop (both panels). Panel B – Visualisations of the crystal structure of the Streptavidin protein, obtained from the PDB Protein Data Bank http://www.pdb.org/. Nine amino acids forming the loop, which can be modified or substituted are identified (bottom right corner). The loop (see also Figure 7) was used in the design of a display system based on the SAPV.