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Table 2 Percentage cytotoxicity on cell membrane measured via LDH leakage using MNP-PEI and MNP-PEI-PEG on SH-SY5Y cells over 1, 4, 24 and 72 h (n = 3 ± SD)

From: The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism

Particle

Incubation time h

  

MNP concentration µgmL-1

  
  

0

6.25

12.5

25

50

100

MNP-PEI

1

10.29 (0.607)

12.89 (0.282)

12.15 (0.152)

12.16 (0.357)

12.66 (0.952)

14.42 (0.997)

 

4

9.73 (0.014)

13.30 (1.052)

13.21 (1.192)

12.38(0.183)

12.16 (0.339)

12.35 (0.428)

 

24

10.26 (0.014)

10.75 (0.080)

11.07 (0.344)

11.38 (0.021)

13.90 (0.132)

24.94 (0.789)*

 

72

11.86 (0.288)

32.43 (2.366)*

35.51 (1.897)*

33.03 (2.103)*

30.86 (1.464)*

31.37 (0.788)*

MNP-PEI-PEG

1

10.44 (0.007)

10.43 (0.526)

9.95 (0.120)

9.85 (0.010)

9.80 (0.288)

9.93 (0.087)

 

4

10.52 (1.539)

11.61 (0.616)

11.66 (0.158)

11.62 (0.350)

11.71 (0.102)

11.63 (0.484)

 

24

10.35 (1.531)

9.02 (0.027)

8.67 (0.153)

8.84 (0.072)

9.00 (0.024)

9.50 (0.295)

 

72

11.13 (0.242)

11.29 (0.591)

11.17 (0.443)

12.11 (2.964)

10.69 (0.254)

12.98 (0.000)

  1. * Denotes a significant increase from basal levels (p < 0.05).