Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel

Table 2 GO function analysis of differential expressed genes at 48 h exposure of silver-NP-hydrogel

Functional GO pathway	REF.-LIST*/Up-exp^#/expected^$	P value
cell communication	4365/231/174.28	p = 1.04E-06
cell-cell signaling	1331/81/53.14	p = 2.14E-04
cell adhesion	1333/77/53.22	p = 8.67E-04
signal transduction	4191/215/167.34	p = 2.37E-05
intracellular signaling cascade (JAK-STAT cascade)	1568/102/62.61	p = 1.02E-06
metabolic process	8267/373/330.08	p = 7.32E-04
lipid metabolic process	1119/94/44.68	p = 7.32E-12
carbohydrate metabolic process	952/69/38.01	p = 1.08E-06
response to stimulus	1798/119/71.79	p = 7.96E-08
transport	2857/164/114.07	p = 6.18E-07
endocytosis	575/43/22.96	p = 9.23E-05
cellular defense response	457/38/18.25	p = 2.75E-05
immune system process	2628/171/104.93	p = 7.69E-11
immune response	756/52/30.19	p = 1.41E-04

* reference list, that is all genes number related to the GO pathway;
^# up-expressed genes number in this study;
^$ expected minimum genes number for activating of signal pathway.
Based on the gene ontology (GO) biological process, the GO pathway, which has theoretically significant activation (p < 1.0E-03), related to up-regulated genes.

ISSN: 1477-3155