Table 1 Relationship between coded and actual values of the variables used for PLGA-CURC formulation
Formulation factors | Coded level of variables | ||||
|---|---|---|---|---|---|
|  | -α | −1 | 0 | 1 | +α |
X1 = Amount of PLGA (mg) | 26.14 | 50 | 85 | 120 | 143.86 |
X2 = PVA (% w/v) | 0.32 | 1.0 | 2.0 | 3.0 | 3.68 |
X3 = Ethyl acetate (ml) | 0.98 | 2 | 3.5 | 5.0 | 6.02 |
Dependent variables | Constraints | ||||
Y1 = Particle Size (nm) | Minimize | ||||
Y2 = Polydispersity | Minimize | ||||
Y3 = Encapsulation efficiency (%) | Maximize | ||||
Y4 = Drug loading (%) | Maximize | ||||