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Table 1 Relationship between coded and actual values of the variables used for PLGA-CURC formulation

From: Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy

Formulation factors Coded level of variables
  −1 0 1
X1 = Amount of PLGA (mg) 26.14 50 85 120 143.86
X2 = PVA (% w/v) 0.32 1.0 2.0 3.0 3.68
X3 = Ethyl acetate (ml) 0.98 2 3.5 5.0 6.02
Dependent variables Constraints
Y1 = Particle Size (nm) Minimize
Y2 = Polydispersity Minimize
Y3 = Encapsulation efficiency (%) Maximize
Y4 = Drug loading (%) Maximize