Table 2 Observed responses in central composite design for PLGA-CURC formulation
Exp. No | Wt. of PLGA (mg) | PVA conc. (% w/v) | Ethyl Acetate (ml) | Particle Size (nm) | Polydispersity | Encapsulation efficiency (%) | Drug loading (%) |
|---|---|---|---|---|---|---|---|
1 | 50 | 1 | 2 | 125.6 | 0.135 | 73.4 | 11.1 |
2 | 120 | 1 | 2 | 142.5 | 0.148 | 63.35 | 11.4 |
3 | 50 | 3 | 2 | 108.5 | 0.125 | 73.84 | 11.3 |
4 | 120 | 3 | 2 | 144.5 | 0.143 | 63.86 | 13.5 |
5 | 50 | 1 | 5 | 81.5 | 0.097 | 83.25 | 14.9 |
6 | 120 | 1 | 5 | 133.8 | 0.116 | 85.5 | 13.2 |
7 | 50 | 3 | 5 | 103.7 | 0.115 | 83.54 | 10.5 |
8 | 120 | 3 | 5 | 136.7 | 0.135 | 84.8 | 15.8 |
9 | 26.14 | 2 | 3.5 | 133.3 | 0.138 | 63.25 | 5.5 |
10 | 143.86 | 2 | 3.5 | 198.8 | 0.172 | 53.46 | 9.4 |
11 | 85 | 0.32 | 3.5 | 158.8 | 0.164 | 88.85 | 13.6 |
12 | 85 | 3.68 | 3.5 | 149.5 | 0.155 | 88.25 | 13.8 |
13 | 85 | 2 | 0.98 | 176.9 | 0.093 | 53.35 | 14.5 |
14 | 85 | 2 | 6.02 | 77.8 | 0.067 | 63.78 | 15.2 |
15 | 85 | 2 | 3.5 | 112.5 | 0.135 | 86.95 | 11.8 |
16 | 85 | 2 | 3.5 | 121.6 | 0.148 | 90.35 | 12.6 |
17 | 85 | 2 | 3.5 | 119.8 | 0.135 | 91.46 | 10.5 |
18 | 85 | 2 | 3.5 | 118.6 | 0.147 | 93.54 | 11.9 |
19 | 85 | 2 | 3.5 | 129.6 | 0.128 | 90.34 | 12.8 |
20 | 85 | 2 | 3.5 | 119.7 | 0.172 | 86.27 | 12.9 |