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Table 3 Formulation factors and parameter variations for process scale up

From: Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy

  PLGA (mg) PVA %(w/v) Ethyl acetate (ml) Aqueous phase (ml) Excess Water (ml) Sonication Tip* Sonication Time (s) Stirrer Speed (rpm) Stirrer Time (h)
Primary optimized conditions 85 1 4.25 15 40 S2 60 2000 4
First stage – 500 mg 500 1 5 20 50 S2 120 2000 4
Second stage – 1 g 1000 1 10 40 60 S14 120 3000 6
Third stage- 2 g 2000 1 20 60 80 S14 180 6000 6
Fourth stage – 5 g 5000 1 50 150 200 S14 300 8000 6
  1. *S2 – soncation tip dia – 2 mm, S14 – sonication tip dia – 14 mm.