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Table 3 Formulation factors and parameter variations for process scale up

From: Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy

 

PLGA (mg)

PVA %(w/v)

Ethyl acetate (ml)

Aqueous phase (ml)

Excess Water (ml)

Sonication Tip*

Sonication Time (s)

Stirrer Speed (rpm)

Stirrer Time (h)

Primary optimized conditions

85

1

4.25

15

40

S2

60

2000

4

First stage – 500 mg

500

1

5

20

50

S2

120

2000

4

Second stage – 1 g

1000

1

10

40

60

S14

120

3000

6

Third stage- 2 g

2000

1

20

60

80

S14

180

6000

6

Fourth stage – 5 g

5000

1

50

150

200

S14

300

8000

6

  1. *S2 – soncation tip dia – 2 mm, S14 – sonication tip dia – 14 mm.