Table 4 Scale up results for large batch production of PLGA-CURC

Primary optimized conditions

129.5 ± 6.9

0.138 ± 0.023

91.4 ± 2.3

12.68 ± 3.5

First stage – 500 mg

135.4 ± 9.4

0.139 ± 0.012

91.12 ± 1.5

11.98 ± 2.5

Second stage – 1 g

142.3 ± 8.9

0.142 ± 0.024

92.13 ± 3.5

11.12 ± 2.6

Third stage- 2 g

148.6 ± 7.7

0.137 ± 0.025

90.67 ± 2.8

10.92 ± 2.3

Fourth stage – 5 g

158.5 ± 9.8

0.141 ± 0.011

90.34 ± 3.2

10.32 ± 1.4