Skip to main content

Table 4 Scale up results for large batch production of PLGA-CURC

From: Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy

  Particle size (nm) Polydispersity index Encapsulation efficiency (%) Drug loading (%)
Primary optimized conditions 129.5 ± 6.9 0.138 ± 0.023 91.4 ± 2.3 12.68 ± 3.5
First stage – 500 mg 135.4 ± 9.4 0.139 ± 0.012 91.12 ± 1.5 11.98 ± 2.5
Second stage – 1 g 142.3 ± 8.9 0.142 ± 0.024 92.13 ± 3.5 11.12 ± 2.6
Third stage- 2 g 148.6 ± 7.7 0.137 ± 0.025 90.67 ± 2.8 10.92 ± 2.3
Fourth stage – 5 g 158.5 ± 9.8 0.141 ± 0.011 90.34 ± 3.2 10.32 ± 1.4