Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy

Table 6 Different kinetic models and regression coefficients of PLGA-CURC formulations ^a

Model	Equation	R²value for burst release (%)	R²value for sustained release (%)
Zero order	$m_{0} - m = k t$	0.997	0.955
First order	$ln m = k t$	0.977	0.976
Higuchi’s model	$m_{0} - m = k t^{1 / 2}$	0.967	0.996
Hixson crowell	$m_{0}^{1 / 3} - m^{1 / 3} = k t$	0.987	0.955

^am₀ is the initial drug amount (100%, when represented as percentage); m the amount of drug remaining at a specific time (calculated as % of m₀); k the rate constant; t is the time.

ISSN: 1477-3155