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Table 6 Different kinetic models and regression coefficients of PLGA-CURC formulations a

From: Scale up, optimization and stability analysis of Curcumin C3 complex-loaded nanoparticles for cancer therapy

Model Equation R2value for burst release (%) R2value for sustained release (%)
Zero order m 0 m = k t 0.997 0.955
First order ln m = k t 0.977 0.976
Higuchi’s model m 0 m = k t 1 / 2 0.967 0.996
Hixson crowell m 0 1 / 3 m 1 / 3 = k t 0.987 0.955
  1. am 0 is the initial drug amount (100%, when represented as percentage); m the amount of drug remaining at a specific time (calculated as % of m 0 ); k the rate constant; t is the time.