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Figure 4 | Journal of Nanobiotechnology

Figure 4

From: Investigating bioconjugation by atomic force microscopy

Figure 4

AFM force spectroscopy. (A) Sample preparation for AFM force spectroscopy experiments often involves attachment of biomolecules to a substrate surface. Shown here is a streptavidin-biotin sandwich attachment method, in which biotinylated bovine serum albumin (BSA) and streptavidin serve to anchor a biotinylated molecule to a surface. Its interaction partner is attached to the AFM tip and interactions between the two molecules can be monitored from AFM force-distance curves. (B) Schematic AFM force-distance curve.

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