From: Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle
Nanomaterial used | Size (nm) | Surface chemistry | Dispersal medium | Proteins identified | Ref |
---|---|---|---|---|---|
Polystyrene NPs | 50, 100 | NH2, COOH | Human Plasma | Coagulation factors, Immunoglobulins, Lipoproteins, Complement proteins, Acute phase proteins | [15] |
Polystyrene NPs | 100 | COOH | Human serum (depleted) | Complement proteins, Plasminogen, Anti-CD4, c4a, Immunoglobulin, Albumin, Complement , Plasminogen | [16] |
Latex NPs | 80-109 | NH2,NHR, NR2,NR3+ COO-, SO−3, SO−4 | Human Serum | Albumin, Apolipoproteins, Immunoglobulins, Hemoglobin, Haptoglobins | [17] |
Copolymer NPs | 70, 200 | - | Human Plasma | Albumin, Apolipoprotiens, Fibrinogen, Immunoglobulins, C4BPαchain | [2] |
MWCNTs | 20-30 | NH2, COOH | Human Plasma | 2 Macroglobulin precursor, Complement factors, plasminogen, Coagulation factors | [8] |
SPIONs | - | - | Human Plasma | Albumin, α1Antitrypsin, Fibrinogen chains, Immunoglobulin chains, Transferrin, Transthyretin | [14] |
Gold | 5, 10, 20 | (PAA) polymer coated | Human Plasma | Albumin, Fibrinogen chains, Apolipoprotein A1 | [18] |
Gold | 15, 40, 80 | - | Bovine Serum | Transport proteins, Coagulation factors, Tissue development proteins | [19] |
TiO2 NPs ZnO NPs Quartz sand Carbon nanotubes SiO2 NPs | - | Silone, alumina, silica coated | Human Plasma | Fibrinogen chains, Immunoglobulin light chains, Fibrin, albumin, ApoA1, Complement component proteins, Fibronectin, | [13] |
SiO2 NPs | 8, 20, 25 | - | Human Plasma | Immunoglobulins, Lipoproteins, Complement proteins, Coagulation proteins, Acute phase proteins, Cellular proteins, Serum proteins | [20] |
TiO2 NPs ZnO NPs SiO2 NPs | - | - | Human Plasma | Albumin, Immunoglobulins, Fibrinogen, Transferrin, Apolipoprotein A1,Complement proteins | [21] |
Magnetic NPs | 50, 200 | Dextran COOH, NH2,PEG COOH, PEG-NH2 | Bovine Serum | Albumin, Apolipoprotein A-1 Complement factors, Vitronectin, Haemoglobin | [22] |