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Table 1 Characteristics of chitosan derivatives: molecular weight (MW) and NP: z averaged particle size (Size), ζ potential (ZP), polydispersity index (PDI) and loading efficiency (LE) of chitosan-based DNA preparations used in this study

From: Fate of TLR-1/TLR-2 agonist functionalised pDNA nanoparticles upon deposition at the human bronchial epithelium in vitro

Formulation

MW

Size

ZP

PDIa

LE

 

(g/mol)

(nm)a

(mV)a

 

(%)a

CTC NP

98,330

232.9 ± 16.1

21.3 ± 1.2

0.248 ± 0.038

n/a

pGFP-loaded CTC NP

98,330

304.1 ± 13.0

17.5 ± 1.6

0.342 ± 0.041

92.5 ± 2.5

pGFP-loaded CTPPC NP

259,000

327.3 ± 16.2

15.8 ± 1.6

0.366 ± 0.053

89.4 ± 3.8

  1. aanalyses were performed in triplicates; n/a, not applicable.