Figure 4

Electron micrographs of thin sections of phage EPTHSWAT–PC-3M cells and the control phage VPEGAFSS–PC-3M cells interactions. The localization of phage particles is revealed by the presence of gold particles in the red circles. At 15 min post-incubation, a lot of phage EPTHSWAT particles had bound and internalized PC-3M cells whereas phage VPEGAFSS had been washed off. At 1 h post-incubation, more phage EPTHSWAT particles were seen internalizing PC-3M cells than the control phage. At 24 h post-incubation, more EPTHSWAT particles had internalized and homed into the nucleus in comparison with the control phage.