Figure 5
From: Metastatic prostate cancer cell-specific phage-like particles as a targeted gene-delivery system
Schematic representation of the rescue of prostate cancer specific phage-like particles by the prostate cancer-specific helper phage EPTHSWAT in E. coli. The blue arrows indicate the replication cycle of the helper phage generating proteins needed for replication and encapsidation of the phagemid, whereas, the maroon arrows show the replication and rescue of phage-like particles. The dotted lines indicate the translocation of the helper phage expressed proteins to the inner membrane where they are involved in assembly. pV binds ss DNA whereas pII nicks ds DNA and pX acts as inhibitor of pII function.