Figure 4

hERG tail current density averages obtained by measuring the hERG tail peak amplitude at 20 mV in baseline conditions and in the presence of curcumin, Formulation HNC-NP, Formulation HNC-PS and Formulation HNC-PS-C hybrid nanocurcumin. The curcumin concentrations were always 6.0, 12 and 18 μM. A: Current density was measured from 7 cells, averaged, normalized against baseline current density, and corrected for time and solvent effects. Statistical comparisons between post-drug exposure and baseline current density levels were made using repeat paired Student’s t-tests (*). Differences were considered significant when p ≤ 0.05. B: Voltage dependency of the hERG tail currents inhibition at the higher concentration of curcumin and hybrid nanoformulations tested (18 μM).