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Table 1 Effect of tested compounds on hERG current density at +20 mV (I +20 )

From: Mitigating prolonged QT interval in cancer nanodrug development for accelerated clinical translation

Compound tested Statistically significant inhibition starting at (μM) Maximal inhibition (%) Statistically significant reversibility of the Washout Calculated IC50 (μM) Voltage dependence
HNC-NP 18 24.8 No n/a Yes
HNC-PS 6 40.2 No n/a Yes
HNC-PS-C 6 25.2 No n/a Yes
Curcumin 12 77.8 No 8.5 Yes
Liposomal curcumin 6 only 30 No n/a No