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Table 2 Effects of ZnPcS 4 -AN-based PDT and/or Dox treatments on erythrogram parameters of healthy and Ehrlich solid tumor-bearing mice

From: Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine

Group

Treatment

RBC (x 106/μL)

HGB (g/dL)

HCT (%)

MCV (fL)

MCH (pg)

MCHC (g/dL)

RDW (%)

1

NC

8.8 ± 0.1

12.8 ± 0.1

31.5 ± 0.3

35.8 ± 0.1

14.5 ± 0.1

40.5 ± 0.2

13.01 ± 0.09

2

CT

8.6 ± 0.2

12.0 ± 0.2

30.7 ± 0.5

35.7 ± 0.3

13.9 ± 0.1**a

38.9 ± 0.2**a

13.6 ± 0.3

3

ZnPc

6.6 ± 0.7**a.*b

9.2 ± 0.9**a.*b

23.3 ± 2.5**a.*b

35.6 ± 0.4

14.2 ± 0.3

39.9 ± 0.5

14.1 ± 0.7

4

LS

8.5 ± 0.1*a.c

11.9 ± 0.2**c

30.5 ± 0.5*a.**c

36.0 ± 0.1

14.08 ± 0.08**a

39.1 ± 0.2**a

13.1 ± 0.2

5

PDT

8.1 ± 0.2**a.*b.d

11.4 ± 0.3**c

29.0 ± 0.6**a.*b

35.7 ± 0.2

14.0 ± 0.1

39.2 ± 0.2

14.0 ± 0.3

6

Dox

7.8 ± 0.3

11.1 ± 0.3

30 ± 1

38 ± 2

14.1 ± 0.3

38 ± 1**a

13.5 ± 0.4

7

ZnPc/Dox

8.0 ± 0.4*a

10.9 ± 0.5

28 ± 1**a

35.25 ± 0.05

13.60 ± 0.00*a.d

38.50 ± 0.00*a.c.d

13.8 ± 0.4

8

Dox/LS

7.6 ± 0.4**a.*b.d

10.9 ± 0.5*a

27 ± 1*a.d.**b

35.8 ± 0.7

14.3 ± 0.1*b

39.9 ± 0.5

13.5 ± 0.6

9

Dox/PDT

8.3 ± 0.2.*c.h

11.8 ± 0.2**c

30.1 ± 0.6*a.**c

36.2 ± 0.3

14.18 ± 0.12*g

39.2 ± 0.1**a.*g

14.2 ± 0.3

 

P-values

0.000

0.000

0.000

0.195

0.018

0.000

0.033

  1. Data were expressed as mean ± SEM (standard error of mean). RBC = Red Blood Cells; HGB = Hemoglobin; HCT = Hematocrit; MCV = Mean Corpuscular Volume; MCH = Mean Corpuscular Hemoglobin; MCHC = Mean Corpuscular Hemoglobin Concentration; RDW = Red cell Distribution Width (represents an indication of the amount of variation - anisocytosis - in cell size); g/dL = grams per deciliter; fL = fentoliters; pg = picograms. P-values of HGB, MCV and RDW were generated by ANOVA, while other p-values were generated by Kruskal-Wallis test. Lower-case letters indicate significant diferences in 2-by-2 comparisons detected by Bonferroni (HGB, MCV and RDW) or Mann–Whitney (other variables) tests, with a = significant compared to group 1; b = significant compared to group 2; c = significant compared to group 3; d = significant compared to group 4; e = significant compared to group 5; f = significant compared to group 6; g = significant compared to group 7; h = significant compared to group 8. Asterisks indicate significant differences (*p < 0.05) or highly significant (**p < 0.01). For details of experimental groups see Table 5.