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Table 4 Effects of ZnPcS 4 -AN-based PDT and/or Dox treatments on biochemical parameters of healthy and Ehrlich solid tumor-bearing mice

From: Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine

G

T

Total bilirubin (mg/dL)

Direct bilirubin (mg/dL)

Indirect bilirubin (mg/dL)

AST (U/L)

ALT (U/L)

GGT (U/L)

Alkaline phosphatase (U/L)

Creatinine (mg/dL)

Urea (mg/dL)

1

NC

0.10 ± 0.00

0.04 ± 0.00

0.06 ± 0.00

71 ± 4

35 ± 2

1.88 ± 0.09

115 ± 9

0.20 ± 0.03

59 ± 2

2

CT

0.10 ± 0.00

0.03 ± 0.00**a

0.08 ± 0.00**a

186 ± 30**a

36 ± 3

1.8 ± 0.3

68 ± 8**a

0.20 ± 0.08

57 ± 5

3

ZnPc

0.10 ± 0.00

0.02 ± 0.00**a

0.08 ± 0.00**a

236 ± 30**a

44 ± 3

2.00 ± 0.00

41 ± 6**a.*b

0.16 ± 0.02

46 ± 3**a

4

LS

0.10 ± 0.00

0.02 ± 0.00**a

0.08 ± 0.00**a

96 ± 20*c

33 ± 6

2.3 ± 0.3

42 ± 9**a.*b

0.44 ± 0.09*a.b.c

39 ± 9*a

5

PDT

0.10 ± 0.00

0.02 ± 0.00

0.08 ± 0.00**a

162 ± 80

30 ± 9

1.9 ± 0.1

44 ± 7**a

0.29 ± 0.05

44 ± 8

6

Dox

0.10 ± 0.00

0.03 ± 0.00*d

0.07 ± 0.00*d

174 ± 20**a

37 ± 4

1.5 ± 0.3*c.d

53 ± 10

0.25 ± 0.06

55 ± 3

7

ZnPc/Dox

0.10 ± 0.00

0.02 ± 0.00**a

0.08 ± 0.00**a

160 ± 10**a

27 ± 2

1.8 ± 0.3

47 ± 10**a

0.25 ± 0.03*c

50 ± 3

8

Dox/LS

0.10 ± 0.00

0.03 ± 0.00*d

0.07 ± 0.00*d

162 ± 20**a.*d

35 ± 4

2.00 ± 0.00

88 ± 20*c.d

0.18 ± 0.03

56 ± 5

9

Dox/PDT

0.3 ± 0.2

0.04 ± 0.01*d.e

0.2 ± 0.2

106 ± 20*a.b.f.**c

25 ± 4

3 ± 1

42 ± 6

0.20 ± 0.02

39 ± 6

 

P-values

0.393

0.000

0.001

0.000

0.247

0.519

0.000

0.067

0.025

  1. Data were expressed as mean ± SEM (standard error of mean). G = Group; T = Treatment; AST = Aspartate Aminotransferase; ALT = Alanine Aminotransferase; GGT = Gamma-Glutamyl Transferase; mg/dL = miligrams per deciliters; ULl = Units per liter. P-values of ALT were generated by ANOVA, while other values were generated by Kruskal-Wallis test. Lower-case letters indicate significant diferences in 2-by-2 comparations detected by Bonferroni (ALT) or Mann–Whitney (other variables) tests, with a = significant compared to group 1; b = significant compared to group 2; c = significant compared to group 3; d = significant compared to group 4; e = significant compared to group 5; f = significant compared to group 6. Asterisks indicate significant differences (*p < 0.05) or highly significant (**p < 0.01 or p < 0.001). For details of experimental groups see Table 5.