Figure 2

Characterization of pH and size stability of GLA-AF with various buffer compositions. (a) pH of buffered GLA-AF’s at the following time points: DM, 1 week, 2 weeks, 1 month, 3 months, 6 months. (b) Particle size of buffered GLA-AF compositions measured at DM, 1 week, 2 weeks, 1 month, 3 months, and 6 months. (c) Polydispersity index (PdI) of buffered GLA-AF compositions measured at DM, 1 week, 2 weeks, 1 month, 3 months, and 6 months. GLA-AF made with ammonium phosphate at 20 or 25 mM, citric acid, or PBS failed to maintain particle size within 50% of the DM value before reaching the 6-month timepoint, thus pH, size, and PdI data for those lots were measured until (and including) the time point at which their size failed this specification.