Short name: Coronal in vivo T
-weighted MRI of mice bearing GL261 gliomas, with superimposed K
colour-coded maps. Detailed legend: A) Representative coronal in vivo T1-weighted images, with superimposed Kep colour-coded maps of two mice bearing a GL261 glioma, administered with Gadoterate Meglumine (left), and GNP (E_2) (right). The black pixels correspond to instances with values above or below the user-established Kep limits (see Methods). The color scale on top shows the range of values found for Kep in each case, as well as their color coding. B) Boxplot for comparison of Kep (min−1) obtained with all in vivo studied animals, using the same contrast agents shown in A). Significant differences (p < 0.05) are marked with a triangle. The limits of the box represent the quartiles 1 (Q1) and 3 (Q3) of the distribution, the central line corresponds to the median (quartile 2) and the whiskers represent the maximum and minimum value in each distribution. The data represented were included in the range [Q1-1.5 IQR - Q3 + 1.5 IQR], being IQR the interquartile range. Outliers are represented outside the whiskers in two ways: as a circle if its value is in the range [Q1-1.5 IQR > value > Q1- 3.0 IQR or Q3 + 1.5 IQR < value < Q1- 3.0 IQR], or as an asterisk if values are above or below this threshold.