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Table 2 RCE ex vivo , RCE in vivo , K ep and IAUC values obtained with in vivo studies

From: A new ex vivo method to evaluate the performance of candidate MRI contrast agents: a proof-of-concept study

CA % Ex vivo RCE % In vivo RCE at T1-max % In vivo RCE at 3 min Kep(min−1) IAUC (A.U.)
Gadoterate meglumine 236.7 ± 14.4 113.1 ± 2.5 113.1 ± 2.5 0.32 ± 0.36 2.8 ± 0.1
GNP (E_2) 201.9 ± 16.1 124.9 ± 8.3* 107.9 ± 2.0* 0.06 ± 0.03* 2.6 ± 0.2*
  1. Detailed legend:
  2. % RCE in vivo is shown both at T1-max of each CA and at 3 min after their administration.
  3. * p < 0.05 in comparison with gadoterate meglumine.