Table 1 Liposome formulation screen for encapsulation of IMQ
From: A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7
Liposome type | Composition | Number of batches | IMQ concentration (mg/ml) | IMQ loading efficiency (%) | % Loss after 0.2-μm filtration | Particle size (Zave, nm) | Polydispersity index |
|---|---|---|---|---|---|---|---|
Anionic | DPPC/DPPG/Cholesterol* | 8 | 0.6 ± 0.1 | 6 ± 1 | 23 ± 12 | 151 ± 20 | 0.17 ± 0.07 |
Cationic | DPPC/DPTAP/Cholesterol | 1 | 0 | 0 | NM | 64 | 0.07 |
Neutral | DOPC/Cholesterol* | 4 | 0.7 ± 0.2 | 7 ± 2 | 45 ± 22 | 73 ± 23 | 0.20 ± 0.01 |