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Figure 4 | Journal of Nanobiotechnology

Figure 4

From: PapMV nanoparticles improve mucosal immune responses to the trivalent inactivated flu vaccine

Figure 4

Mice vaccinated with PapMV nanoparticles adjuvanted TIV showed an increased protection to an influenza challenge with influenza strain normally lethal to TIV vaccinated mice. Mice vaccinated twice with TIV adjuvanted or not by PapMV nanoparticles by intranasal (i.n.) or subcutaneous (s.c.) routes were challenged with 250 pfu of A/WSN/1933 (H1N1) influenza virus. Mice were monitored for weight loss (A), symptoms levels (B) and survival (C) for 14 days. Statistical analysis is applied between groups of the same immunization ways. *P < 0.05, **P < 0.01 and ***P < 0.001.

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