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Table 3 Mean size, PDI and zeta potential in bidistilled water of lyophilised empty and tyrphostin AG-1478 -loaded NLC after storage at 0°C for 3 months in the dark

From: Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells

Sample

Size (nm)

PDI

ζ-potential (mV)

L.C. (wt%)

 

Before storage

After storage

Before storage

After storage

Before storage

After storage

Before storage

After storage

Empty NLC-A

139.7

134.9

0.38

0.39

-20.1 ± 5.5

-19.1 ± 4.5

----

----

Drug-loaded NLC-A

176.2

179.5

0.41

0.44

-30.3 ± 7.7

-29.4 ± 7.9

2.8

2.6

Empty NLC-B

62.6

64.4

0.46

0.49

-18.7 ± 4.6

-19.5 ± 4.9

----

----

Drug-loaded NLC-B

80.1

84.4

0.49

0.50

-28.5 ± 10.3

-29.9 ± 16.2

1.7

1.5

Empty NLC-C

175.9

175.9

0.34

0.34

-35.7 ± 5.2

-35.7 ± 5.2

----

----

Drug-loaded NLC-C

209.7

220.5

0.46

0.48

-46.9 ± 8.4

-42.7 ± 7.3

24.0

21.4

Empty NLC-D

185.5

192.5

0.29

0.32

-36.7 ± 5.9

-32.7 ± 4.4

----

----

Drug-loaded NLC-D

189.3

199.3

0.42

0.48

-38.4 ± 6.5

-36.3 ± 4.4

24.0

21.8