Effect of fullerene on conspicuous facial pores. (a) Reduction of the conspicuous facial pores after fullerene treatment for 8 weeks. The graph shows the mean ± standard deviation (n = 10). *p < 0.05, Wilcoxon signed-rank test. (b) The photos of conspicuous pores on the cheek by VISIA® in the representative case (43-year-old female) before (upper panel) and after fullerene treatment for 8 weeks (lower panel) are shown. The number of conspicuous pores has decreased from 170 to 103. (c) Using dermoscopy, a regression of conspicuous pores (triangles) is observed in the same case.