A lipid/nanoparticle assembly (LNA) containing hydrophobic nanoparticles embedded within vesicle bilayers. This illustration, which was adapted from Jang et al , depicts the incorporation of nanoparticles that have been surface modified with hydrophobic tails (e.g. decanethiol, shown in gray) into a lipid bilayer. Lipid disordering and bilayer disruption will be dependent on the size and surface chemistry of the nanoparticles. The image is not to scale.