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Table 1 Sizing and zeta-potential of drug, cationic lipid and anionic polyelectrolyte in separate or as assemblies

From: Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro

Dispersion [DODAB] (mM) [AmB] (mM) [CMC] (mg/mL) D ± δ (nm) ζ ± δ (mV)
AmB in water --- 0.005 --- 433 ± 5 -26 ± 3
DODAB BF 1 - - - --- 79 ± 2 41 ± 2
DODAB BF/AmB 1 0.005 --- 79 ± 1 42 ± 2
DODAB BF/AnB/CMC 1 0.005 0.01 88 ± 1 40 ± 1
  1 0.005 0.1 145 ± 1 32 ± 2
  1 0.005 1 90 ± 2 -50 ± 2
AmB in water --- 0.050 --- 360 ± 4 -26 ± 3
AmB in IGP --- 0.050 --- 75 ± 2 -27 ± 1
DODAB BF in IGP 0.1 - - - --- 75 ± 1 40 ± 1
AmB/DODAB BF 0.1 0.050 --- 195 ± 3 9 ± 1
AmB/DODAB BF/CMC 0.1 0.050 0.001 199 ± 1 16 ± 1
  0.1 0.050 0.01 1280 ± 80 4 ± 1
  0.1 0.050 0.1 230 ± 2 -34 ± 1
  1. Zeta-average diameter (D) and zeta-potentials (ζ) for different dispersions aiming at formulation of AmB in cationic lipid DODAB and CMC. Dispersions were prepared either in Milli-Q water or in IGP buffer.