Table 1 Sizing and zeta-potential of drug, cationic lipid and anionic polyelectrolyte in separate or as assemblies
Dispersion | [DODAB] (mM) | [AmB] (mM) | [CMC] (mg/mL) | D ± δ (nm) | ζ ± δ (mV) |
|---|---|---|---|---|---|
AmB in water | --- | 0.005 | --- | 433 ± 5 | -26 ± 3 |
DODAB BF | 1 | - - - | --- | 79 ± 2 | 41 ± 2 |
DODAB BF/AmB | 1 | 0.005 | --- | 79 ± 1 | 42 ± 2 |
DODAB BF/AnB/CMC | 1 | 0.005 | 0.01 | 88 ± 1 | 40 ± 1 |
1 | 0.005 | 0.1 | 145 ± 1 | 32 ± 2 | |
1 | 0.005 | 1 | 90 ± 2 | -50 ± 2 | |
AmB in water | --- | 0.050 | --- | 360 ± 4 | -26 ± 3 |
AmB in IGP | --- | 0.050 | --- | 75 ± 2 | -27 ± 1 |
DODAB BF in IGP | 0.1 | - - - | --- | 75 ± 1 | 40 ± 1 |
AmB/DODAB BF | 0.1 | 0.050 | --- | 195 ± 3 | 9 ± 1 |
AmB/DODAB BF/CMC | 0.1 | 0.050 | 0.001 | 199 ± 1 | 16 ± 1 |
0.1 | 0.050 | 0.01 | 1280 ± 80 | 4 ± 1 | |
0.1 | 0.050 | 0.1 | 230 ± 2 | -34 ± 1 |