Figure 3From: Formulation of polylactide-co-glycolic acid nanospheres for encapsulation and sustained release of poly(ethylene imine)-poly(ethylene glycol) copolymers complexed to oligonucleotidesInfluence of sonication intensity and vessel volume on the size of 72 kDa lauryl ester end-capped nanospheres encapsulated with PEG-PEI-AO polyplex. The size distribution within a single prepared sample of nanospheres formulated in a high volume chamber with a low intensity (38 W) sonication (full line) and a low volume chamber with a high intensity (51 W) sonication (broken line) were determined using DLS. Polyplex loaded nanospheres formulated with a low volume chamber and a high sonication intensity show a more uniform size distribution and smaller mean size.Back to article page