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Figure 8 | Journal of Nanobiotechnology

Figure 8

From: Silver nanoparticles inhibit VEGF-and IL-1β-induced vascular permeability via Src dependent pathway in porcine retinal endothelial cells

Figure 8

Effect of Ag-NP and PP2 on VEGF-and IL-1β-induced Src phosphorylation. PRECs were treated with VEGF and IL-1β in presence and absence of 100 nM Ag-NP or 10 μM PP2 for 1 hour. Level of Src phosphorylation (Y419) in cell lysate (1 × 107 cells) was checked by sandwich ELISA. VEGF (25 ng/ml) or IL-1β (10 ng/ml) treatments significantly increase the Src phosphorylation compared to the control. Both Ag-NP and PP2 significantly decreased the VEGF-and IL-1β-induced Src phosphorylation in PRECs. Data are means ± SEM representing similar results was obtained in three independent experiments (n = 3, *P < 0.05 vs control, **P < 0.01 vs control).

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