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Table 1 Antiviral effect of silver nanoparticles against HIV-1 strains

From: Mode of antiviral action of silver nanoparticles against HIV-1

HIV-1 strain

Tropism (co-receptor)

IC50 (mg/mL)*

HeLa cells CC50 (mg/mL)*

TI

IIIB

T (X4)

0.44 (± 0.3)

3.9 (± 1.6)

8.9

Eli

T (X4)

0.42 (± 0.2)

 

9.3

Beni

T (X4)

0.19 (± 0.1)

 

20.5

96USSN20

T (X4)/M (R5)

0.36 (± 0.2)

 

12.5

Bal

M (R5)

0.27 (± 0.2)

 

14.4

BCF01

M (R5)

0.37 (± 0.3)

 

10.5

AZTRV

T (X4)

0.19 (± 0.01)

 

20.5

NNRTIRV

T (X4)

0.61 (± 0.24)

 

6.4

PIRV

T (X4)

0.91 (± 0.09)

 

4.3

3TCRV

T (X4)

0.73 (± 0.12)

 

5.3

SaquinavirRV

T (X4)

0.81 (± 0.11)

 

4.8

  1. *Values represent the mean of the triplicate ± standard error of the mean.
  2. NNRTI: non-nucleoside retrotranscriptase inhibitor, PI: protease inhibitor, RV: resistant virus