Figure 4

TEM of TCRV internalization into Vero cells. TEM micrographs depict Vero cells infected with untreated TCRV (a, b), 10 nm (uncoated, 50 μg/ml) treated TCRV (c, d), or 25 nm (uncoated, 50 μg/ml) treated TCRV (e, f) with b, d, and f being zoomed-in images of the white squares of a, b, and c. Images g and h depict virus and the Ag-NPs localizing within the same cell, and i and j depict the interaction of TCRV with the Ag-NPs outside of the cell. White arrows are pointing towards the virus and black arrows show the Ag-NPs.