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Figure 11 | Journal of Nanobiotechnology

Figure 11

From: Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis

Figure 11

The PLGA-PEG mediated PS-341 delivery to murine lungs controls Pa -LPS induced CF lung inflammation. The Cftr-/- mice (n = 3, each group) were treated with Pa-LPS and/or PLGA-PEGPS341. The PLGA-PEGPS341 treated mice exhibited significant decrease in LPS induced NFκB expression and nuclear localization, and decline in number of inflammatory, macrophages (Mac-3+) and neutrophil (NIMP-R14+) cells. Changes in nuclear (NFκB) and total protein (Mac-3+ and NIMP-R14) expression levels are shown in bottom panels (densitometry units). The PLGA-PEG mediated PS-341 lung delivery controls Pa-LPS induced inflammation. Scale: white bar = 50 μm, red bar = 10 μm, black = 100 μm.

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