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Figure 4 | Journal of Nanobiotechnology

Figure 4

From: On-chip constructive cell-Network study (I): Contribution of cardiac fibroblasts to cardiomyocyte beating synchronization and community effect

Figure 4

Electrophysiological measurement of synchronization of two cardiomyocytes with/without a fibroblast between them. (a) A phase-contrast image of two cardiomyocytes (A, B; yellow arrows) and two micropipettes (white arrows) for electrophysiological recording. Two cardiomyocytes were connected through the channel fabricated in the agarose layer on a chip. (b) Time course of two cardiomyocytes' beating action potentials. (c) A phase-contrast image of a lined-up two cardiomyocytes (C, D; yellow arrows) and single fibroblast (green arrow) network (72 hours after cultivation started). Two micropipettes (white arrows) were put on two cardiomyocytes for electrophysiological recording. Two cardiomyocytes were connected through the channel fabricated in the agarose layer on a chip. (d) Time course of two cardiomyocytes' beating action potentials connected by a fibroblast. In detail, see Table 1.

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