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Figure 5 | Journal of Nanobiotechnology

Figure 5

From: Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism

Figure 5

Inhibition of DCAMKL-1 and Notch signaling inhibits EMT. (A) siRNA-mediated knockdown of DCAMKL-1 in tumor xenografts results in increased expression of pri-miR-200a miRNA. Tumor xenografts treated with NP-siDCAMKL-1, DAPT and siDCAMKL-1+DAPT demonstrated a downregulation of EMT transcription factors ZEB1, ZEB2 and increased the expression of E-cadherin mRNA (B), decreased snail and slug mRNA expression (C). Values in the bar graph are given as average ± SEM, and asterisks denote statistically significant differences (P < 0.01) compared with control (NP alone).

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