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Table 1 Polymeric nanoparticles: general advantages and drawbacks of the various preparation methods (reproduced from ref [10] with permission from Elsevier).

From: Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

Method

Simplicity of Procedure

Need for Purification

Facility Scaling-up

EE (%)

Safety of Compounds

Polymerization of monomers

     

Emulsion polymerization

     

Organic

Low

High

NR

Low

Low

Aqueous

High

High

High

High

Medium

Interfacial polymerization

Low

High

Medium

High

Low

Preformed polymers

     

Synthetic

     

Emulsification/solvent evaporation

High

Low

Low

Medium

Medium

Solvent displacement and interfacial deposition

High

NR

NR

High

Medium

Salting out

High

High

High

High

Low

Emulsion/solvent diffusion

Medium

Medium

High

High

Medium

Natural

     

Albumin

NR

High

NR

Medium

Low

Gelatin

NR

High

NR

Medium

Low

Polysaccharides

     

Alginate

High

Medium

High

High

High

Chitosan

High

Medium

High

High

High

Agarose

Medium

High

NR

NR

High

Desolvation

NR

High

NR

Low

Low

  1. EE, Encapsulation Efficiency; NR, no reference available