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Figure 4 | Journal of Nanobiotechnology

Figure 4

From: Nanoscaled carborane ruthenium(II)-arene complex inducing lung cancer cells apoptosis

Figure 4

Activation of the apoptosis signal pathway. (A) Western blotting in vitro. Cell lysates were prepared from the cells treated with 50 μM ruthenium (II)-arene complex, 100 μM ruthenium (II)-arene complex. HCC827 cells without treatment were used as a control. The following antibodies were used: anti-cleaved Caspase-8, anti-cleaved Caspase-9, anti-cleaved Caspase-3, and anti-PARP antibody. GAPDH was served as a loading control. (B) Western blotting in vivo. Tumor lysates were prepared from the cells treated with 50 μmol/kg ruthenium (II)-arene complex, 100 μmol/kg ruthenium (II)-arene complex. HCC827 cells without treatment were used as a control. The following antibodies were used: anti-cleaved Caspase-8, anti-cleaved Caspase-9, anti-cleaved Caspase-3, and anti-PARP antibody. GAPDH was served as a loading control.

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