Figure 11

Mitochondrial membrane potential and by DNA fragmentation of A549 cells treated with selol-PVM/MA nanocapsules (SPN) and untreated cell (control cells, Ctl) at different times. *p < 0.05 for Ctl 48 h vs. SPN 48 h; p < 0.001 for Ctl 72 h vs. SPN 72 h (a). Representative histogram showing a sample of control cells (red line) and a sample of SPN-treated cells (blue line) after 72 h (b). DNA fragmentation in SPN-treated or untreated A549 cells at different times. *p < 0.001 for Ctl 48 h vs. SPN 48 h; p < 0.001 for Ctl 72 h vs. SPN 72 h (c). Representative histogram showing sub-G1 (DNA fragmented), G1, S and G2/M populations for Ctl (red line) and SPN-treated cells (blue line) after 72 h (d).