PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenocarcinoma cells

Table 1 Thermodynamic stability and dispersibility studies of Selol-PVM/MA nanocapsules

Formulation	Hydrodynamic diameter ± S.D. (nm)	Polydispersity index	Zeta potential (mV)
Room temperature
Day 0	344.4 ± 4.8^a	0.061	−29.3
Day 15	349.7 ± 8.2^a	0.049	−29.7
Day 30	338.9 ± 6.4^a	0.046	−29.2
Day 45	344.3 ± 2.0^a	0.034	−26.5
Day 60	336.6 ± 4.6^a	0.043	−29.4
4°C
Day 0	344.4 ± 4.8^a	0.061	−29.3
Day 1	390.2 ± 1.0^b	0.054	−29.3
Day 15	391.3 ± 7.5^b	0.044	−25.1
Day 30	373.9 ± 15.0^b	0.046	−27.8
Day 45	381.6 ± 8.9^b	0.031	−30.1
Day 60	380.6 ± 7.1^b	0.039	−27.3
−20°C
Day 0	344.4 ± 4.8^a	0.061	−29.3
Day 1	414.2 ± 7.7^c	0.074	−29.2
Day 15	408.2 ± 10.7^c	0.113	−27.0
Day 30	471.0 ± 1.3^d	0.195	−27.4
Day 45	615.2 ± 13.3^e	0.278	−29.8
Day 60	566.3 ± 14.8^f	0.196	−26.5
Freezing (−20°C) and thawing cycle
No cycle	344.4 ± 4.8	0.061	−29.3
I	414.2 ± 7.74	0.074	−29.2
II	414.1 ± 10.0	0.066	−28.9
III	406.7 ± 4.5	0.035	−28.9
IV	410.2 ± 4.7	0.045	−28.1
V	416.5 ± 4.3	0.064	−22.9
VI	405.5 ± 6.0	0.046	−28.5
VII	425.8 ± 0.9	0.079	−28.8
VIII	467.3 ± 9.9	0.143	−27.0
IX	486.5 ± 17.1^*	0.106	−28.8
X	495.1 ± 1.0^*	0.177	−30.8
XI	509.3 ± 6.6^*	0.221	−28.9
XII	566.2 ± 3.5^*	0.364	−28.7
XIII	865.1 ± 50.4^*	0.581	−27.7
XIV	989.1 ± 26.6^*	0.433	−26.9
XV	1027.5 ± 60.7^*	0.393	−28.8

All values were expressed as the means ± standard error of the mean. Different letters indicate significant differences between SPN treatment for one day at RT compared with a given time and/or storage condition (p < 0.05). *Significantly different compared with the first cycle of freezing (−20°C) and thawing (p < 0.05).

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