Skip to main content

Table 1 Thermodynamic stability and dispersibility studies of Selol-PVM/MA nanocapsules

From: PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenocarcinoma cells

Formulation Hydrodynamic diameter ± S.D. (nm) Polydispersity index Zeta potential (mV)
Room temperature    
Day 0 344.4 ± 4.8a 0.061 −29.3
Day 15 349.7 ± 8.2a 0.049 −29.7
Day 30 338.9 ± 6.4a 0.046 −29.2
Day 45 344.3 ± 2.0a 0.034 −26.5
Day 60 336.6 ± 4.6a 0.043 −29.4
4°C    
Day 0 344.4 ± 4.8a 0.061 −29.3
Day 1 390.2 ± 1.0b 0.054 −29.3
Day 15 391.3 ± 7.5b 0.044 −25.1
Day 30 373.9 ± 15.0b 0.046 −27.8
Day 45 381.6 ± 8.9b 0.031 −30.1
Day 60 380.6 ± 7.1b 0.039 −27.3
−20°C    
Day 0 344.4 ± 4.8a 0.061 −29.3
Day 1 414.2 ± 7.7c 0.074 −29.2
Day 15 408.2 ± 10.7c 0.113 −27.0
Day 30 471.0 ± 1.3d 0.195 −27.4
Day 45 615.2 ± 13.3e 0.278 −29.8
Day 60 566.3 ± 14.8f 0.196 −26.5
Freezing (−20°C) and thawing cycle    
No cycle 344.4 ± 4.8 0.061 −29.3
I 414.2 ± 7.74 0.074 −29.2
II 414.1 ± 10.0 0.066 −28.9
III 406.7 ± 4.5 0.035 −28.9
IV 410.2 ± 4.7 0.045 −28.1
V 416.5 ± 4.3 0.064 −22.9
VI 405.5 ± 6.0 0.046 −28.5
VII 425.8 ± 0.9 0.079 −28.8
VIII 467.3 ± 9.9 0.143 −27.0
IX 486.5 ± 17.1* 0.106 −28.8
X 495.1 ± 1.0* 0.177 −30.8
XI 509.3 ± 6.6* 0.221 −28.9
XII 566.2 ± 3.5* 0.364 −28.7
XIII 865.1 ± 50.4* 0.581 −27.7
XIV 989.1 ± 26.6* 0.433 −26.9
XV 1027.5 ± 60.7* 0.393 −28.8
  1. All values were expressed as the means ± standard error of the mean. Different letters indicate significant differences between SPN treatment for one day at RT compared with a given time and/or storage condition (p < 0.05). *Significantly different compared with the first cycle of freezing (−20°C) and thawing (p < 0.05).