Table 1 Mean size (nm), polydispersity index (PDI) and ζ-potential (mV) in bi-distilled water, phosphate buffer solution (PBS) and NaCl 0.9 wt% of empty and Fluticasone propionate (FP)-loaded nanoparticles
Sample | Dispersing medium | Mean size (nm) | PDI | Zeta potential (mV)(± S.D.) | EE%(w/w) |
|---|---|---|---|---|---|
Empty | PBS pH 7.4 | 133.7 | 0.243 | −15.1 ± 3.78 | ----- |
|  | NaCl 0.9% | 132.5 | 0.215 | −12.3 ± 4.16 | ----- |
|  | H2O | 115.9 | 0.285 | −27.8 ± 3.21 | ----- |
FP-loaded | PBS pH 7.4 | 178.7 | 0.266 | −14.3 ± 2.44 | 76.8 ± 0.04 |
|  | NaCl 0.9% | 189.6 | 0.244 | −13.3 ± 4.56 | 76.8 ± 0.05 |
|  | H2O | 129.9 | 0.330 | −31.3 ± 4.50 | 76.8 ± 0.04 |
Empty 4 months) | H2O | 137.9 | 0.247 | −26.6 ± 3.13 | ----- |
Empty (10 months) | H2O | 149.9 | 0.235 | −25.4 ± 2.15 | ----- |
FP-loaded (4 months) | H2O | 143.2 | 0.323 | −28.3 ± 2.72 | 74.7 ± 0.06 |
FP-loaded (10 months) | H2O | 145.6 | 0.334 | −27.5 ± 4.50 | 72.5 ± 0.03 |