Figure 8

A schematic representation of mitochondrial ROS implicated in DNA damage and apoptosis induced by TiO ₂ NP exposure, with and without TLR4 over-expression. The figure shows the site of induction and inhibition of respiratory complexes and oxidative stress molecules involved in ROS generation in HepG2 cells exposed to TiO₂ NPs with and without TLR4 over-expression. (+) indicate the sites of activation and (-) show the sites of inhibition.