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Table 1 Induction of gene mRNA expression in HepG2 cells transfected with TLR4 expression vectors

From: Molecular mechanism of DNA damage induced by titanium dioxide nanoparticles in toll-like receptor 3 or 4 expressing human hepatocarcinoma cell lines

Symbols of genes Description of the genes Fold regulation
ABL1 C-abl oncogen 1, non-receptor tyrosine kinase 1.56
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.86
ATM Ataxia telangiectasia mutated 1.91
ATR Ataxia telangiectasia and Rad3 related 1.42
BRCA1 Breast cancer 1, early onset 1.23
CHEK2 CHK2 checkpoint homolog (S.pombe) 1.41
CIDEA Cell death-inducing DFFA-like effector a 1.32
GADD45A Growth arrest and DNA-damage inducible, alpha 1.77
GML Glycosylphosphatidylinositol anchored molecule like protein 1.3
IP6K3 Inositol hexaphosphate kinase 3 2.23
MAPK6 Mitogen-activated protein kinase 6 1.34
MBD4 Methyl-CpG binding domain protein 4 1.65
BTG2 B-cell translocation gene 2 1.43
RAD18 RAD18 homolog (S. cerevisiae) 1.34
RAD21 RAD21 homolog (S. pombe) 1.39
SMC1A Structural maintenance of chromosomes 1A 1.62
PNKP Polynucleotide kinase 3′-phosphate 1.27
  1. Cells exposed to 10 μg/ml TiO2 NPs for 48 h prior to gene expression analysis with PCR array. Fold regulation values greater than 1 indicate positive regulation (up-regulation).