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Table 1 Induction of gene mRNA expression in HepG2 cells transfected with TLR4 expression vectors

From: Molecular mechanism of DNA damage induced by titanium dioxide nanoparticles in toll-like receptor 3 or 4 expressing human hepatocarcinoma cell lines

Symbols of genes

Description of the genes

Fold regulation

ABL1

C-abl oncogen 1, non-receptor tyrosine kinase

1.56

APEX1

APEX nuclease (multifunctional DNA repair enzyme) 1

1.86

ATM

Ataxia telangiectasia mutated

1.91

ATR

Ataxia telangiectasia and Rad3 related

1.42

BRCA1

Breast cancer 1, early onset

1.23

CHEK2

CHK2 checkpoint homolog (S.pombe)

1.41

CIDEA

Cell death-inducing DFFA-like effector a

1.32

GADD45A

Growth arrest and DNA-damage inducible, alpha

1.77

GML

Glycosylphosphatidylinositol anchored molecule like protein

1.3

IP6K3

Inositol hexaphosphate kinase 3

2.23

MAPK6

Mitogen-activated protein kinase 6

1.34

MBD4

Methyl-CpG binding domain protein 4

1.65

BTG2

B-cell translocation gene 2

1.43

RAD18

RAD18 homolog (S. cerevisiae)

1.34

RAD21

RAD21 homolog (S. pombe)

1.39

SMC1A

Structural maintenance of chromosomes 1A

1.62

PNKP

Polynucleotide kinase 3′-phosphate

1.27

  1. Cells exposed to 10 μg/ml TiO2 NPs for 48 h prior to gene expression analysis with PCR array. Fold regulation values greater than 1 indicate positive regulation (up-regulation).