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Figure 1 | Journal of Nanobiotechnology

Figure 1

From: Investigation of size–dependent cell adhesion on nanostructured interfaces

Figure 1

A schematic representation of the fabrication of the polymeric nanopillar arrays. (a) Nanosphere lithography is utilized to produce a single-layer closely packed structure. (b) The diameters of the polystyrene beads are reduced to a specific size by the oxygen-plasma process. (c) A layer of nickel is evaporated on the top of the polystyrene beads. (d) The polystyrene beads are dissolved with dichloromethane. (e) The nickel film serves as the etching mask for the silicon-hole array in ICP etching. (f) The nickel film is removed by the etchant solution. (g) The silicon-hole arrays are used as molds for replication by spin-coating the photo-curable polymers. The UV-curable adhesive is cured under UV radiation for 10 minutes. (h) After being peeled away from the silicon mold, well-ordered periodic polymeric nanopillar arrays are obtained. (i) The polymeric nanopillar arrays are then used to culture cells.

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