Figure 12From: Effects of an 11-nm DMSA-coated iron nanoparticle on the gene expression profile of two human cell lines, THP-1 and HepG2 Comparison of the FeRGs, GO terms and KEGG pathways for all four cell types. A: Common genes, GO terms and KEGG pathways for the RAW264.7 and THP-1 cells. B: Common genes, GO terms and KEGG pathways for the Hepa1-6 and HepG2 cells. C: Common genes, GO terms and KEGG pathways for all four cell lines. RAW, RAW264.6; THP, THP-1; Hepa, Hepa1-6; HepG, HepG2. All GO terms and KEGG pathways have p values < 0.05 except for five KEGG pathways with p value > 0.05 (indicated by shading). D: GO analysis of genes common to the RAW264.7 and THP-1 cells. E: Comparison of the numbers of FeRGs in 8 pathways of the THP-1 and RAW264.7 cells. a to h, pathways in image A. F: Expression of Id3 gene in the four cell lines treated with FeNPs. Symbols of cells and treatments in image A, B and F: R, RAW264.6; T, THP-1; A, Hepa1-6; G, HepG2; 1, treated with 50 μg/mL of FeNPs; 2, treated with 100 μg/mL of FeNPs. For example, T1 and T2 indicate THP-1 cells treated with 50 μg/mL and 100 μg/mL of FeNPs, respectively. R12, R1 and R2; T12, T1 and T2; A12, A1 and A2; G12, G1 and G2. IN, enriched by induced genes; RE, enriched by repressed genes. M, metabolism.Back to article page