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Table 1 In vitro cytotoxicity of drug loaded nanoparticles

From: Lactosaminated mesoporous silica nanoparticles for asialoglycoprotein receptor targeted anticancer drug delivery

Cells

Treatment

IC50 (nM)

Time (h)

DTX-MSNs

DTX-Lac-MSNs

HepG2

24

---

---

48

122.43 ± 8.02

51.6 ± 5.51*

72

117.04 ± 20.38

31.55 ± 6.35*

SMMC7721

24

---

---

48

72.77 ± 11.14

16.65 ± 3.31*

72

32.61 ± 6.24

10.51 ± 1.01*

  1. IC50 values of DTX-MSNs and DTX-Lac-MSNs against HepG2 and SMMC7721 cells after 24, 48 and 72 h of treatment. Data represent mean ± SD (n = 6).
  2. *Significantly different from DTX-MSNs according to a Student’s t-test and Mann–Whitney U test (p < 0.05).