Figure 6

Images of tumor cells in vitro and in vivo . A: 3D reconstruction of HepG2 cells treated with 10 mg/L GGMPN with green (a), yellow (b), and red (c) fluorescence separately to analyze intracellular distribution (Scale bar = 100 μm), image of HepG2 cells treated with GGMPN labeled with green, yellow and red fluorescence (d). B: Fluorescence image of tumor after intravenous injection of 10 mg/L GGMPN (miR-122 with red fluorescent) solution for 2 h; a) bright mouse image, b) fluorescence intensity scan of xenograft tumor, c) red fluorescence near the tumor. C: TUNEL staining of HepG2 xenograft tumors after various treatments; 1) untreated control, 2) transfected cells with miR-122, 3) treatment cells with GGMPN, quantitative analysis of apoptotic rate after various treatments (C). D: Distribution of Au levels in the liver, the brain, the bone, the muscle, the intestines, and the tumor, respectively. The group numbers for the mouse organs are as follows: (1) bone, (2) skin, (3) muscle, (4) intestine, (5) liver and (6) tumor.