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Figure 10 | Journal of Nanobiotechnology

Figure 10

From: Multifunctional mitoxantrone-conjugated magnetic nanosystem for targeted therapy of folate receptor-overexpressing malignant cells

Figure 10

Quantitative PCR analysis of apoptotic genes in MCF7 cells treated with the PEGylated FA-MTX-MNPs. Panels A, B, and C show the expression of Caspase 9, BAx and AKt, respectively. As a housekeeping gene, 18 s rRNA was used to normalize Ct values using the Pfaffl method. Data are expressed as mean values of independent triplicates (mean ± SD). Asterisks represent statistical difference (p < 0.05) with untreated control. FA: folic acid. MTX: mitoxantrone. MNPs: magnetic nanoparticles. Ct: threshold cycle. UT: untreated control.

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