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Table 3 Pharmacokinetic parameters of LA and RAN released from AAS-NLCs and AAS-SLNs in rat dermis measured using in vivo microdialysis

From: Nanostructured lipid carriers for percutaneous administration of alkaloids isolated from Aconitum sinomontanum

Parameter

AAS-NLCs

AAS-SLNs

LA

RAN

LA

RAN

Tmax (h)

7.70 ± 0.84

8.00 ± 0.50

7.70 ± 0.45

7.50 ± 0.00

Cmax (ng/mL)

207.45 ± 29.89*

46.60 ± 9.56*

65.93 ± 6.37

10.07 ± 1.93

MRT0–t (h)

6.04 ± 0.03

6.24 ± 0.07

6.11 ± 0.05

6.04 ± 0.07

AUC0–t (ng/mL × h)

1,239.07 ± 176.39*

248.44 ± 50.85*

378.72 ± 56.04

56.16 ± 8.89

  1. Mean ± SD, n = 5, * p < 0.05 vs. AAS-SLNs.