Parameter | AAS-NLCs | AAS-SLNs | ||
---|---|---|---|---|
LA | RAN | LA | RAN | |
Tmax (h) | 7.70 ± 0.84 | 8.00 ± 0.50 | 7.70 ± 0.45 | 7.50 ± 0.00 |
Cmax (ng/mL) | 207.45 ± 29.89* | 46.60 ± 9.56* | 65.93 ± 6.37 | 10.07 ± 1.93 |
MRT0–t (h) | 6.04 ± 0.03 | 6.24 ± 0.07 | 6.11 ± 0.05 | 6.04 ± 0.07 |
AUC0–t (ng/mL × h) | 1,239.07 ± 176.39* | 248.44 ± 50.85* | 378.72 ± 56.04 | 56.16 ± 8.89 |