Skip to main content

Table 2 MIC, MIC50, MIC90 and MBC for MDR (n = 56) and antimicrobial susceptible microorganisms (n = 34)

From: Comparison of methods to detect the in vitro activity of silver nanoparticles (AgNP) against multidrug resistant bacteria

Microorganism Citrate Chitosan PVA Ag Sulfadiazin Ag Nitrate Commercial AgNPs
MIC MBC MIC MBC MIC MBC MIC MBC MIC MBC MIC MBC
A. baumannii MDR (A1) 3.4 13.5 6.7 6.7 ≥54 ≥54 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A2) 3.4 3.4 6.7 6.7 27 27 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A3) 3.4 13.5 6.7 6.7 13.5 13.5 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A4) 3.4 13.5 6.7 6.7 ≥54 ≥54 13.5 13.5 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A5) 3.4 13.5 6.7 6.7 13.5 13.5 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A6) 3.4 13.5 6.7 6.7 13.5 13.5 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A7) 3.4 27 6.7 6.7 13.5 27 6.7 13.5 3.4 13.5 ≥10 ≥10
A. baumannii MDR (A8) 3.4 27 6.7 27 13.5 13.5 6.7 13.5 3.4 13.5 ≥10 ≥10
A. baumannii MDR (A9) 3.4 27 6.7 6.7 13.5 13.5 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A10) 3.4 3.4 6.7 6.7 13.5 13.5 13.5 13.5 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A11) 3.4 13.5 6.7 6.7 13.5 27 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii MDR (A12) 3.4 3.4 6.7 6.7 27 27 13.5 13.5 3.4 3.4 ≥10 ≥10
MIC50 A. baumannii MDR 3.4 6.7 13.5 6.7 3.4 ≥10
MIC90 A. baumannii MDR 3.4 6.7 ≥54 13.5 3.4 ≥10
A. baumannii S (AS1) 3.4 3.4 3.4 6.7 6.7 13.5 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii S (AS2) 1.6 3.4 1.6 1.6 6.7 13.5 6.7 13.5 3.4 3.4 ≥10 ≥10
A. baumannii S (AS3) 3.4 3.4 3.4 3.4 6.7 13.5 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii S (AS4) 3.4 3.4 3.4 3.4 27 27 6.7 6.7 3.4 3.4 ≥10 ≥10
A. baumannii S (AS5) 3.4 3.4 3.4 6.7 ≥54 ≥54 6.7 6.7 3.4 3.4 ≥10 ≥10
MIC50 A. baumannii S 3.4 3.4 6.7 6.7 3.4 ≥10
MIC90 A. baumannii S 3.4 3.4 ≥54 6.7 3.4 ≥10
S. maltophilia MDR (MO9) 1.6 13.5 6.7 6.7 ≥54 ≥54 6.7 6.7 3.4 3.4 ≥10 ≥10
S. maltophilia MDR (MO11) 1.6 3.4 6.7 6.7 ≥54 ≥54 6.7 6.7 6.7 6.7 ≥10 ≥10
MIC50 S. maltophilia MDR 1.6 6.7 ≥54 6.7 3.4 ≥10
MIC90 S. maltophilia MDR 1.6 6.7 ≥54 6.7 6.7 ≥10
P. aeruginosa MDR (P1) 3.4 3.4 6.7 13.5 27 ≥54 6.7 6.7 1.6 1.6 ≥10 ≥10
P. aeruginosa MDR (P2) 3.4 6.7 6.7 13.5 13.5 27 13.5 13.5 3.4 6.7 ≥10 ≥10
P. aeruginosa MDR (P3) 3.4 3.4 6.7 13.5 13.5 27 13.5 13.5 3.4 3.4 ≥10 ≥10
P. aeruginosa MDR (P4) 3.4 13.5 6.7 13.5 13.5 ≥54 13.5 13.5 6.7 ≥27 ≥10 ≥10
P. aeruginosa MDR (P5) 3.4 3.4 6.7 13.5 13.5 27 6.7 6.7 3.4 6.7 ≥10 ≥10
MIC50 P. aeruginosa MDR 3.4 6.7 13.5 13.5 3.4 ≥10
MIC90 P. aeruginosa MDR 3.4 6.7 27 13.5 6.7 ≥10
P. aeruginosa S (PS1) 3.4 34 6.7 13.5 13.5 13.5 6.7 6.7 3.4 13.5 ≥10 ≥10
P. aeruginosa S (PS2) 3.4 3.4 6.7 6.7 13.5 ≥54 13.5 13.5 6.7 13.5 ≥10 ≥10
P. aeruginosa S (PS3) 3.4 1.6 3.4 3.4 ≥54 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
P. aeruginosa S (PS4) 1.6 1.6 3.4 6.7 13.5 13.5 3.4 13.5 1.6 3.4 ≥10 ≥10
P. aeruginosa S (PS5) 1.6 3.4 6.7 13.5 13.5 27 6.7 6.7 3.4 3.4 ≥10 ≥10
P. aeruginosa S (PS6) 1.6 3.4 6.7 13.5 6.7 ≥54 6.7 13.5 3.4 3.4 ≥10 ≥10
P. aeruginosa S (PS7) 1.6 3.4 3.4 13.5 6.7 13.5 13.5 13.5 6.7 6.7 ≥10 ≥10
P. aeruginosa ATCC 27853 S (MO18) 3.4 6.7 13.5 13.5 13.5 ≥54 6.7 6.7 3.4 3.4 ≥10 ≥10
MIC50 P. aeruginosa S 1.6 6.7 13.5 6.7 3.4 ≥10
MIC90 P. aeruginosa S 3.4 13.5 ≥54 13.5 6.7 ≥10
Enterobacteriaceae MDR (K1) 6.7 6.7 6.7 6.7 ≥54 ≥54 13.5 13.5 6.7 ≥27 ≥10 ≥10
Enterobacteriaceae MDR (K2) 6.7 6.7 6.7 6.7 ≥54 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae MDR (K3) 6.7 13.5 6.7 6.7 13.5 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae MDR (K4) 6.7 6.7 6.7 6.7 ≥54 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae MDR (K5) 6.7 6.7 6.7 6.7 27 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae MDR (K6) 6.7 13.5 6.7 6.7 27 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae MDR (K7) 6.7 6.7 6.7 6.7 27 27 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae MDR (K9) 6.7 6.7 6.7 6.7 ≥54 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae MDR (K14) 6.7 27 6.7 13.5 ≥54 ≥54 13.5 13.5 6.7 ≥27 ≥10 ≥10
Enterobacteriaceae MDR (MO13) 3.3 3.3 3.3 3.3 13.5 13.5 13.5 13.5 6.7 ≥27 ≥10 ≥10
Enterobacteriaceae MDR (MO8) 3.3 13.5 6.7 6.7 ≥54 ≥54 13.5 13.5 3.4 3.4 ≥10 ≥10
Enterobacteriaceae MDR (MO10) 3.3 3.3 6.7 6.7 ≥54 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
MIC50 Enterobacteriaceae MDR 6.7 6.7 ≥54 13.5 6.7 ≥10
MIC90 Enterobacteriaceae MDR 6.7 6.7 ≥54 13.5 6.7 ≥10
Enterobacteriaceae S (ENB1) 3.4 3.4 6.7 6.7 27 27 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae S (ENB2) 6.7 6.7 3.4 6.7 ≥54 ≥54 13.5 13.5 13.5 13.5 ≥10 ≥10
Enterobacteriaceae S (ENB3) 3.4 3.4 3.4 3.4 13.5 13.5 13.5 13.5 3.4 6.7 ≥10 ≥10
Enterobacteriaceae S (ENB4) 6.7 6.7 3.4 6.7 27 27 13.5 13.5 6.7 ≥27 ≥10 ≥10
Enterobacteriaceae S (ENB5) 6.7 6.7 6.7 6.7 27 27 13.5 ≥27 6.7 6.7 ≥10 ≥10
Enterobacteriaceae S (ENB6) 6.7 6.7 6.7 6.7 27 27 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae S (ENB7) 6.7 6.7 3.4 3.4 13.5 13.5 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae S (ENB8) 3.4 3.4 3.4 3.4 13.5 27 13.5 13.5 6.7 6.7 ≥10 ≥10
Enterobacteriaceae S (ENB9) 3.4 27 3.4 3.4 ≥54 ≥54 13.5 13.5 6.7 6.7 ≥10 ≥10
MIC50 Enterobacteriaceae S 6.7 3.4 27 13.5 6.7 ≥10
MIC90 Enterobacteriaceae S 6.7 6.7 ≥54 13.5 13.5 ≥10
S. aureus MRSA (S1) 6.7 6.7 3.4 27 ≥54 ≥54 13.5 13.5 13.5 ≥27 ≥10 ≥10
S. aureus MRSA (S2) 6.7 13.5 3.4 6.7 ≥54 ≥54 ≥27 ≥27 13.5 ≥27 ≥10 ≥10
S. aureus MRSA (S3) 6.7 13.5 3.4 3.4 ≥54 ≥54 ≥27 ≥27 13.5 ≥27 ≥10 ≥10
S. aureus MRSA (S4) 6.7 13.5 3.4 3.4 ≥54 ≥54 ≥27 ≥27 13.5 ≥27 ≥10 ≥10
S. aureus MRSA (S5) 6.7 13.5 3.4 3.4 ≥54 ≥54 13.5 13.5 13.5 13.5 ≥10 ≥10
S. aureus MRSA (S6) 6.7 13.5 3.4 27 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MRSA (S7) 6.7 13.5 3.4 3.4 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MRSA (S8) 6.7 13.5 3.4 3.4 27 27 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MRSA (MO1) 6.7 27 3.4 27 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MRSA (MO2) 6.7 13.5 3.4 3.4 ≥54 ≥54 13.5 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MRSA (MO3) 6.7 13.5 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MRSA (MO4) 6.7 13.5 6.7 27 ≥54 ≥54 ≥27 ≥27 13.5 ≥27 ≥10 ≥10
S. aureus MRSA (MO5) 6.7 13.5 6.7 27 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MRSA (MO6) 13.5 27 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MRSA (MO7) 13.5 13.5 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
MIC50 S. aureus MRSA 6.7 3.4 ≥54 ≥27 13.5 ≥10
MIC90 S. aureus MRSA 13.5 6.7 ≥54 ≥27 13.5 ≥10
S. aureus MSSA (MSSA1) 13.5 27 6.7 27 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MSSA (MSSA2) 6.7 13.5 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MSSA (MSSA3) 6.7 13.5 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MSSA (MSSA4) 6.7 13.5 6.7 ≥54 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MSSA (MSSA5) 6.7 13.5 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus MSSA (MSSA6) 6.7 13.5 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
S. aureus ATCC29213 (MO17) 13.5 27 3.4 6.7 ≥54 ≥54 ≥27 ≥27 13.5 ≥27 ≥10 ≥10
S. epidermidis INCQS198 (MO16) 6.7 6.7 6.7 6.7 27 27 6.7 13.5 6.7 6.7 ≥10 ≥10
MIC50 S. aureus MSSA 6.7 6.7 ≥54 ≥27 13.5 ≥10
MIC90 S. aureus MSSA 13.5 6.7 ≥54 ≥27 13.5 ≥10
Enterococcus sp. VRE (V1) 6.7 27 6.7 27 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
Enterococcus sp. VRE (V2) 6.7 27 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
Enterococcus sp. VRE (V3) 6.7 27 6.7 6.7 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
Enterococcus sp. VRE (V4) 6.7 27 6.7 13.5 ≥54 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
Enterococcus sp. VRE (V5) 6.7 27 6.7 13.5 27 ≥54 ≥27 ≥27 13.5 13.5 ≥10 ≥10
Enterococcus sp. VRE (V6) 6.7 13.5 3.4 13.5 ≥54 ≥54 ≥27 ≥27 6.7 13.5 ≥10 ≥10
Enterococcus sp. VRE (V7) 6.7 27 3.4 6.7 27 ≥54 ≥27 ≥27 6.7 13.5 ≥10 ≥10
Enterococcus sp. VRE (V8) 6.7 27 6.7 6.7 13.5 13.5 ≥27 ≥27 13.5 13.5 ≥10 ≥10
MIC50 Enterococcus sp. VRE 6.7 6.7 ≥54 ≥27 13.5 ≥10
MIC90 Enterococcus sp. VRE 6.7 6.7 ≥54 ≥27 13.5 ≥10
Enterococcus sp. VSE (VSE1) 6.7 27 6.7 13.5 27 ≥54 ≥27 ≥27 ≥27 ≥27 ≥10 ≥10
Enterococcus sp. VSE (VSE2) 6.7 6.7 6.7 13.5 ≥54 ≥54 13.5 ≥27 ≥27 ≥27 ≥10 ≥10
Enterococcus sp. VSE (VSE3) 13.5 13.5 3.4 3.4 ≥54 ≥54 ≥27 ≥27 ≥27 ≥27 ≥10 ≥10
Enterococcus sp. VSE (VSE4) 6.7 6.7 6.7 6.7 ≥54 ≥54 13.5 13.5 13.5 13.5 ≥10 ≥10
Enterococcus sp. VSE (VSE5) 6.7 6.7 6.7 6.7 ≥54 ≥54 13.5 13.5 13.5 13.5 ≥10 ≥10
Enterococcus sp. VSE (VSE6) 6.7 6.7 6.7 6.7 ≥54 ≥54 13.5 ≥27 13.5 ≥27 ≥10 ≥10
MIC50 Enterococcus sp. VSE 6.7 6.7 ≥54 13.5 13.5 ≥10
MIC90 Enterococcus sp. VSE 13.5 6.7 ≥54 ≥27 ≥27 ≥10
MDR (N = 54)
 MIC50 MDR 6.7 6.7 ≥54 13.5 6.7 ≥10
 MIC90 MDR 6.7 6.7 ≥54 ≥27 13.5 ≥10
Susceptible (N = 36)
 MIC50 Susceptible 6.7 6.7 ≥54 13.5 6.7 ≥10
 MIC90 Susceptible 6.7 6.7 ≥54 ≥27 13.5 ≥10
TOTAL (N = 90)             
 MIC50 6.7 6.7 ≥54 13.5 6.7 ≥10
 MIC90 6.7 6.7 ≥54 ≥27 13.5 ≥10