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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Antitumor activity of vorinostat-incorporated nanoparticles against human cholangiocarcinoma cells

Fig. 5

Antitumor activity of vorinostat or vorinostat-NP in HuCC-T1 tumor xenograft mice model. (dose 50 mg vorinostat/kg) a tumor volume; b body weight; c TUNEL assay (×400) of extracted tumor tissues. HuCC-T1 human CCA cells (1 × 107) were implanted into the back of BALb/C nude mouse. 2 weeks later, vorinostat, empty-NPs or vorinostat-NPs were injected subcutaneously beside the solid tumor and the day of drug injection was set as day 0. Tumor volume was calculated using the formula V = (a × [b]2)/2, with a being the largest and b being the smallest diameter. For TUNNEL assay, tumors were isolated and fixed with 4 % formamide after 30 days of injection

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